Oxyneedling (oxygenated needling) is a new technique developed by the MBE R&D team, based on the unique combination of two very effective methods: needling and Oxygen Infusion.

What makes this treatment so unique and effective are the peculiarities of each one of the two techniques, needling and Oxygen Infusion, which are further strengthened thanks to their combined use.

In fact, Oxyneedling not only allows a more effective penetration of the active ingredients applied (meso-oxy-needling) but carries out an important intrinsic action through an intensive oxygenation of the deep dermis, the activation of the microcirculation and the stimulation of the matrix with neo formation of type I and III collagen.

Clinical studies have shown that Oxyneedling allows the practitioner to obtain enhanced results compared with the independent use of the two techniques: needling stimulates collagen type III and elastin, while Oxygen Infusion stimulates angiogenesis, with maintenance of a good cytomorphosis, improvement of hyaluronic acid quality and reorganization of collagen and elastic fibres.

Oxygenated needling allows us to stimulate the production of growth factors which can trigger various cellular mechanisms connected to tissue growth such as angiogenesis, macrophage chemotaxis, proliferation, migration of fibroblasts and collagen synthesis.

For  regeneration  to  be  possible,  skin  cells  must ‘communicate’ with each other, using ‘messengers’ produced by the cells involved in the regeneration process  (growth  factors)  to  exchange  biochemical information.

There are many growth factors involved in the oxygenated needling procedure with Oxygen Infusion:

• Platelet Derived Growth Factors (PDGFaa, PDGFbb, PDGFab): these growth factors trigger mitogenesis of the stem cells in our tissues and assist the synthesis of the extracellular matrix; they also trigger the replication of the endothelial cells and assist angiogenesis
 • Transforming Growth Factors (TGF-alpha, TGF-beta): they trigger the synthesis of DNA, the proliferation of the connective tissue and of the mesenchymal stem cells. They assist collagen synthesis
• Insulin-like Growth Factors (IGF-I, IGF-II): Important in wound healing
• Epidermal Growth Factor (EGF): it triggers the proliferation and differentiation of epidermis cells and co-stimulates angiogenesis, the re-epithelisation and collagen activity
• Vascular Endothelial Growth Factor (VEGF): is involved in processes such as inflammation and angiogenesis. It induces an increase in the permeability of the capillaries, generating an oedema.
• Fibroblast Growth Factor: it triggers fibroblast growth.

Thanks to this innovative technique, treated patients experienced visible improvement in acne scars and stretch marks. On top of this, red stretch marks and chrono-aging related alterations were substantially corrected.

The treatment is not ablative and is ideal for long lasting results.

Compared to traditional needling, oxygenated needling achieves enhanced results:
- Needling treatment stimulates type III collagen and elastin
- Oxygen Infusion triggers angiogenesis, maintaining good cytomorphosis, improves the quality of hyaluronic acid and reorganizes collagen and elastic fibres.

Moreover, for those operators who have a unit not produced by MBE therefore performing only oxygen spray gun treatments, MBE Medical Division has developed a special Oxyneedling handpiece which combines the spray oxygen function (typically less effective than Oxygen Infusion) with the needling one.